With the current boom in details technology, we look its application in almost every aspect of our life. Bioinformatics is the subject, which deals with the application of details cutting molecule diagram the field of biology, for example usage of computing force for drug designing, protein modeling, sequencing genomes and proteins and so on. Pathway curation is one branch or component of bioinformatics. A pathway is a representation of a set of related reactions in a provided context, i. glycolysis, Krebs cycle or apoptosis [1].
Due to the fact that of extensive research, with tools like High-throughput genomics and DNA microarrays, researchers have accumulated high volumes of data that are many times too huge for manual assessment. Mathematical and statistical analysis shall be done to structure the huge data volumes. Based on different computational algorithms, the tool generates pathways along with pictorial representations for easy understanding. Significant biological reactions are more lucid when projected on pathway diagrams rather than being represented within the shape of a huge set of tabular data. Generally a biological pathway diagram is used to describe molecular biology processes in a graphical way.
This new region of pathway representation has created the role of a Biocurator. Biocurators also called scientific curators, data curators or annotators are also recognized as the museum catalogers regarding the World large web age. Like a Biocurator He or She should be can capture and integrate the knowledge from different sources for example databases and scientific literature into a pathway. The Biocurator should also help the data with relevant annotations and make this scientific data accessible to the scientific community. Multiple programs should be can access the pathway diagrams and details in a sharable format to facilitate its use in studies tool.
Apart from this in a pathway diagram the pathway entities like proteins, tiny molecules, lipid molecules etc and the relation between the entities need to be created explicit. To make a pathway user friendly different proteins or metabolites involved within the pathway should be connected to a database entry. This entry should be linked to the experimental evidence from scientific literature which details regarding the function and interactions of these specific proteins or metabolites with other proteins within the pathway. The categories of modifications for e. , phosphorylation, glycosylation, acetylation etc receiving location during any biological process should possibly be represented with correct experimental help from scientific literature.
The pathway should be treated as an interacting network wherein the reactions between metabolites or gene products are represented. The pathway, in general shows different reactions receiving location gradually in response to external stimuli. This ultimately leads to neither activation or repression of a set of genes resulting into phenotypic changes that is of an usual interest to researchers, academicians, doctors etc. The collaboration between authors, journals and biocurators shall facilitate the exchange of data between journal publications and databases and in turn make the signaling pathways, metabolic pathways, sickness pathways etc a readymade tool to every biologist. Combined effort of Biocurators, researchers, academic institutions and funding agencies shall promote Biocuration like a professional career.
A better understanding regarding the pathways shall help the pharmaceutical businesses to creation new drugs and academicians and studies personals to carry out studies in new areas. References [1] Waagmeester AS, Kelder T, Evelo CT. The role of bioinformatics in pathway curation. Genes and amp; nutrition 2008 Dec;3 3-4? 139-42.
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